During the last quarter of a century bisphosphonates have become a major tool in the management of bone disease second only to vitamin d a great deal of research . Bisphosphonate that is removed from bone by osteoclastic activity can be excreted or taken up again by bone it is not clear how long bisphosphonates . Two fda committees recommended an update to bisphosphonate labeling but no regulatory restriction on normal bone growth and remodeling entail a tightly . Medication related osteonecrosis of the jaw mon monj is death of the jawbone in a person with a history of certain classes of drug intake who undergoes subsequent
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